research advances
Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.
March 2012
featured articles
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Twist to open
A structure of an engineered potassium channel suggests a novel model for the gating mechanism.
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Topping off the proteasome
The structure of the entire proteasome complex provides insight into key functions while raising questions for future studies.
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research highlights
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Intrinsic regulationThe structure of the cyclic-nucleotide binding homology domain from a KCNH family members suggests the channel is regulated by an intrinsic ligand.
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Microscopy: Better resolution for structured-illumination microscopyThe use of a photoswitchable fluorescent protein allows nonlinear structured-illumination microscopy of cellular structures at 50 nanometer resolution.
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technical highlights
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Refining protein structure prediction
Molecular dynamics simulations are shown to systematically improve template-based models of protein structure.
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Just blot and see
A simple method for transferring proteins onto EM grids may speed up single-particle analyses of large protein complexes.
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